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Quirk, Gregory J.

One or more keywords matched the following properties of Quirk, Gregory J.

Property	Value
keywords	prefrontal cortex
overview	My research focuses on the neural circuits of fear regulation, using rodent and human models of fear conditioning, extinction, and active avoidance. My lab uses a variety of experimental techniques including multichannel unit recording, optogenetics, immunocytochemistry, electrical stimulation, and computational modeling. We focus on how the prefrontal cortex influences fear-related activity in the amygdala, thalamus and striatum. This work is applicable to PTSD and OCD, and is funded by the National Institute of Mental Health. My lab has been in Puerto Rico for 18 years and consists of approximately 14 students, post-docs, and technicians, from the U.S., Puerto Rico, and other parts of Latin America. My long-term goal is to promote neuroscience research and training in Latin America.

Property

Value

keywords

prefrontal cortex

overview

My research focuses on the neural circuits of fear regulation, using rodent and human models of fear conditioning, extinction, and active avoidance. My lab uses a variety of experimental techniques including multichannel unit recording, optogenetics, immunocytochemistry, electrical stimulation, and computational modeling. We focus on how the prefrontal cortex influences fear-related activity in the amygdala, thalamus and striatum. This work is applicable to PTSD and OCD, and is funded by the National Institute of Mental Health. My lab has been in Puerto Rico for 18 years and consists of approximately 14 students, post-docs, and technicians, from the U.S., Puerto Rico, and other parts of Latin America. My long-term goal is to promote neuroscience research and training in Latin America.

One or more keywords matched the following items that are connected to Quirk, Gregory J.

Item Type	Name
Academic Article	Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.
Academic Article	Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure.
Academic Article	Induction of fear extinction with hippocampal-infralimbic BDNF.
Academic Article	Prefrontal control of fear: more than just extinction.
Academic Article	Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses.
Academic Article	Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear.
Academic Article	Gating of fear in prelimbic cortex by hippocampal and amygdala inputs.
Academic Article	Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study.
Academic Article	Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit.
Academic Article	A temporal shift in the circuits mediating retrieval of fear memory.
Academic Article	Enhancement of fear extinction with deep brain stimulation: evidence for medial orbitofrontal involvement.
Academic Article	Hippocampal--prefrontal BDNF and memory for fear extinction.
Academic Article	Revisiting the role of infralimbic cortex in fear extinction with optogenetics.
Academic Article	Bidirectional Modulation of Extinction of Drug Seeking by Deep Brain Stimulation of the Ventral Striatum.
Academic Article	Circuit-Based Corticostriatal Homologies Between Rat and Primate.
Academic Article	Less fear, more diversity.
Academic Article	The effect of repeated exposure to ethanol on pre-existing fear memories in rats.
Academic Article	An Avoidance-Based Rodent Model of Exposure With Response Prevention Therapy for Obsessive-Compulsive Disorder.
Academic Article	Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex.
Academic Article	Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex.
Academic Article	Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance.
Academic Article	Prefrontal circuits signaling active avoidance?retrieval and extinction.
Academic Article	Functional disruption in prefrontal-striatal network in obsessive-compulsive disorder.
Academic Article	Neurons in medial prefrontal cortex signal memory for fear extinction.
Academic Article	Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons.
Academic Article	Learning not to fear, faster.
Academic Article	The role of ventromedial prefrontal cortex in the recovery of extinguished fear.
Academic Article	Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner.
Academic Article	Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex.
Academic Article	Fear extinction in rats: implications for human brain imaging and anxiety disorders.
Academic Article	Prefrontal mechanisms in extinction of conditioned fear.
Academic Article	Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction.
Academic Article	Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear.
Academic Article	Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert.
Academic Article	Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex.
Academic Article	Prefrontal involvement in the regulation of emotion: convergence of rat and human studies.
Academic Article	Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction.
Academic Article	Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex.
Academic Article	Extinction circuits for fear and addiction overlap in prefrontal cortex.
Academic Article	Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons.
Concept	Prefrontal Cortex
Academic Article	Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance.
Grant	Neurocircuitry of OCD: Effects of Modulation
Academic Article	A Novel Insular/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior.

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prefrontal cortex